Endocrine Abstracts

Background: Whether combination therapy of levothyroxine and liothyronine increases the risk of atrial fibrillation remains a topic of debate.Objectives: The objective of this study was to investigate the risk of atrial fibrillation in individuals with hypothyroidism treated with a combination of levothyroxine and liothyronine.Methods: We conducted a retrospective cohort study using individual-level linkage of Danish nationwide reg...

Background: Subclinical hypothyroidism is associated with a number of cardiovascular risk factors such as hypertension, hypercholesterolemia, and diastolic dysfunction, but only limited data exist on long-term outcome of levothyroxine substitution therapy.Objectives: To examine effects of levothyroxine substitution treatment on mortality in patients with subclinical hypothyroidism.Study design: Historical cohort study.<p class=...

ESE Young Investigator AwardBackground: It is still discussed if subclinical hyperthyroidism and ‘high-normal’ thyroid function are risk-factors for cardiovascular mortality.Objectives: To examine the risk of cardiovascular and all-cause mortality in relation to subclinical hyperthyroidism.Methods: Patients consulting their general practitioner from 2000 to 2009 in Copenhagen, Denmark, who ...

Introduction: Hypothyroidism has detrimental effects on the cardiovascular system but controversy remains over the benefit of levothyroxine substitution in heart failure (hf). The aim of this register based cohort study was to examine the effects of levothyroxine treatment on all-cause mortality in patients with hf.Methods: The study cohort comprised all Danish citizens aged ≥18 years admitted with hf in 1997–2012 and still alive 30 days after...

Introduction: Subclinical hypothyroidism (SCH) is a common condition and can lead to impaired systolic and diastolic cardiac function. However, controversy remains over the potential benefits of levothyroxine substitution in patients with SCH and concomitant heart disease. We aimed to examine the effects of levothyroxine treatment on all-cause mortality in patients diagnosed with SCH and heart disease.Methods: Primary care patients aged 18 years and olde...